Coronavirus Vulnerability Unveiled: Targeting the Mac1 Domain A recent study featured in mBio sheds light on a potential Achilles’ heel in coronaviruses, including the infamous SARS-CoV-2 (the virus behind COVID-19) and MERS-CoV. Researchers have discovered that these viruses are susceptible to inhibitors that target a small protein domain known as Mac1, or the “macrodomain.” This…